Reverse phase-high performance liquid chromatographic method and high performance thin layer chromatography were developed for the determination of Fosinopril Sodium in pharmaceutical dosage form and validated. The chromatographic conditions comprised of a reversed-phase C18 column (250 x 4.6 mm), 5 µ with a mobile phase consisting of Methanol: Buffer (0.2 % H3PO4) in the ratio (85:15v/v). Flow rate was 1 mL / min. Detection was carried out at 215 nm. The retention time was 8.5 min. It was subjected to acid & alkali hydrolysis, oxidation, photochemical and thermal degradation. The linearity curve was found to be linear over 40-160 µg/ml. The value of correlation coefficient, slope and intercept were, 0.9999, 40.29 & 13.06 respectively. The method was found to be accurate over 97.5% – 102.0%. The method was found to be precise with % RSD 0.100–0.114 for intra-day (n=3) and % RSD 0.110–0.130 for inter-day (n=3). The LOD and LOQ were found to be 1.00 μg/ml and 3.00 μg/ml respectively.
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